The human genome is huge, consisting of 3 billion
base pairs (3!109 bp or 3000 Mb) per haploid
set of chromosomes. Only 30% of mammalian
DNA is related to genes (900 Mb),
whereas 70% of the DNA is not (2100 Mb).
Coding DNA in genes accounts for only 3% (90
Mb) of the total amount of DNA. The bulk of
DNA (70%) consists of sequences that are repeated
many times (repetitive DNA). Characteristic
types of repetitive DNA are tandem repeats.
Depending on their size and pattern,
different types are distinguished: classic satellite
DNA, minisatellites, and microsatellites. Together
they constitute 14% of the total DNA (420
Mb). More than half of human DNA (56%) consists
of repeats interspersed throughout the
genome. The most important types are long terminal
repeats (LTRs), LINEs (long interspersed
nuclear elements), SINEs (short interspersed
nuclear elements), and transposons.
Sunday, April 12, 2009
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