Range of resolution within the genome

The resolution ranges from a whole chromosome
or part of a chromosome isolated from a
somatic hybrid cell line (1) to the sequence of
the nucleotide pairs (5) and cloned DNA fragments
(2). Each fragment is characterized by
distinct landmarks (restriction sites or
sequence-tagged sites, STS, see Genome Maps).
They are aligned according to their contiguous
linear orientation in a contig (3), which can be
mapped (4). The individual clones can be
sequenced (sequence map, 5). This approach is
called a clone-by-clone approach in contrast to
“shotgun sequencing”